Abstract
Diabetic ulcers are one of the most serious and costly chronic complications for diabetic patients. Hyperglycemia-induced oxidative stress may play an important role in diabetes and its complications. The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rats. Diabetic wound model was prepared by making an incision with full thickness in STZ-induced diabetic rats. Wounds from diabetic rats were treated with 10% hemin ointment for 21 days. Increase of HO-1 protein expression enhanced anti-inflammation and antioxidant in diabetic rats. Furthermore, HO-1 increased the levels of VEGF and ICAM-1 and expressions of CBS and CSE protein. In summary, HO-1 promoted the wound closure by augmenting anti-inflammation, antioxidant, and angiogenesis in diabetic rats.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Administration, Cutaneous
-
Angiogenesis Inducing Agents / administration & dosage
-
Angiogenic Proteins / metabolism
-
Animals
-
Anti-Inflammatory Agents / administration & dosage
-
Antioxidants / administration & dosage
-
Cytokines / metabolism
-
Diabetes Mellitus, Experimental / complications
-
Diabetes Mellitus, Experimental / enzymology*
-
Diabetes Mellitus, Experimental / pathology
-
Enzyme Induction
-
Heme Oxygenase (Decyclizing) / biosynthesis*
-
Hemin / administration & dosage
-
Inflammation Mediators / metabolism
-
Male
-
Neovascularization, Physiologic / drug effects
-
Ointments
-
Oxidative Stress / drug effects
-
Rats, Sprague-Dawley
-
Skin / blood supply
-
Skin / drug effects
-
Skin / enzymology*
-
Skin / injuries
-
Skin / pathology
-
Time Factors
-
Wound Healing* / drug effects
-
Wounds, Penetrating / complications
-
Wounds, Penetrating / drug therapy
-
Wounds, Penetrating / enzymology*
-
Wounds, Penetrating / pathology
Substances
-
Angiogenesis Inducing Agents
-
Angiogenic Proteins
-
Anti-Inflammatory Agents
-
Antioxidants
-
Cytokines
-
Inflammation Mediators
-
Ointments
-
Hemin
-
Heme Oxygenase (Decyclizing)
-
Hmox1 protein, rat