Novel Anthraquinone-based Derivatives as Potent Inhibitors for Receptor Tyrosine Kinases

M Stasevych; V Zvarych; V Lunin; T Halenova; O Savchuk; O Dudchak; M Vovk; V Novikov

doi:10.4103/0250-474x.169062

Novel Anthraquinone-based Derivatives as Potent Inhibitors for Receptor Tyrosine Kinases

Indian J Pharm Sci. 2015 Sep-Oct;77(5):634-7. doi: 10.4103/0250-474x.169062.

Authors

M Stasevych¹, V Zvarych¹, V Lunin¹, T Halenova², O Savchuk², O Dudchak¹, M Vovk³, V Novikov¹

Affiliations

¹ Lviv Polytechnic National University, S. Bandera Street 12, Lviv-13, 79013, Ukraine.
² Educational and Scientific Centre, Institute of Biology, Taras Shevchenko National University of Kyiv, Volodymyrska Street 64/13, Kyiv 01601, Ukraine.
³ Institute of Organic Chemistry of NASU, Murmanska Street 5, 02660 Kyiv-94, Ukraine.

Abstract

The influence of new derivatives of 9,10-anthraquinone with benzoylthiourea, thiazole, triazole and amino acid fragments on the activity of membrane-associated tyrosine kinases was investigated. Inhibitors of protein tyrosine kinase activity of the membrane fraction, as promising agents to search for new potential anticancer agents among the studied compounds, were discovered.

Keywords: Anthraquinone; amino acid; protein tyrosine kinase activity; thiazole; thiourea; triazole.