One-step ligand exchange and switching from hydrophobic to water-stable hydrophilic superparamagnetic iron oxide nanoparticles by mechanochemical milling

Katalin V Korpany; Cristina Mottillo; Jill Bachelder; Shoronia N Cross; Pengcheng Dong; Simon Trudel; Tomislav Friščić; Amy Szuchmacher Blum

doi:10.1039/c5cc07107k

One-step ligand exchange and switching from hydrophobic to water-stable hydrophilic superparamagnetic iron oxide nanoparticles by mechanochemical milling

Chem Commun (Camb). 2016 Feb 18;52(14):3054-7. doi: 10.1039/c5cc07107k.

Authors

Katalin V Korpany¹, Cristina Mottillo¹, Jill Bachelder¹, Shoronia N Cross¹, Pengcheng Dong², Simon Trudel², Tomislav Friščić¹, Amy Szuchmacher Blum¹

Affiliations

¹ Department of Chemistry, McGill University, 801 Sherbrooke St. W., H3A 0B8 Montreal, Canada. amy.blum@mcgill.ca tomislav.friscic@mcgill.ca.
² Department of Chemistry, Centre for Advanced Solar Materials, and Institute for Quantum Science and Technology, University of Calgary, 2500 University Drive N.W., Calgary, ABT2N 1N4, Canada.

PMID: 26794225
DOI: 10.1039/c5cc07107k

Abstract

We describe a simple, rapid methodology for the synthesis of water-stable iron oxide nanoparticles (IONPs) compatible with a variety of aqueous buffers, based on mechanochemical milling exchange of covalently bound surface ligands on pre-fabricated oleic acid-protected IONPs. Application of milling for IONP ligand exchange eliminates steps required for transforming hydrophobic into negatively charged, water-soluble superparamagnetic IONPs.

Publication types

Research Support, Non-U.S. Gov't