The likelihood of having a serum PSA level of ≥2.5 ng/mL according to the degree of fatty liver disease in a screened population

Jong Hyun Yoon; Hee Jo Yang; Jae Heon Kim; Seung Whan Doo; Won Jae Yang; Jiyoung Hwang; Seong Sook Hong; Suyeon Park; Dae Yeon Cho

doi:10.5489/cuaj.2395

The likelihood of having a serum PSA level of ≥2.5 ng/mL according to the degree of fatty liver disease in a screened population

Can Urol Assoc J. 2015 Nov-Dec;9(11-12):E868-72. doi: 10.5489/cuaj.2395. Epub 2015 Dec 14.

Authors

Jong Hyun Yoon¹, Hee Jo Yang¹, Jae Heon Kim¹, Seung Whan Doo¹, Won Jae Yang¹, Jiyoung Hwang², Seong Sook Hong², Suyeon Park³, Dae Yeon Cho⁴

Affiliations

¹ Department of Urology, Soonchunhyang University College of Medicine, Seoul, Republic of Korea;
² Department of Radiology, Soonchunhyang University College of Medicine, Seoul, Republic of Korea;
³ Department of Biostatistics, Soonchungyang University, College of Medicine, Seoul, Republic of Korea;
⁴ Department of Urology, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.

Abstract

Introduction: We sought to investigate the impact of fatty liver disease (FLD) on prostate cancer (PCa) screening by estimating the odds of having a prostate-specific antigen (PSA) value over the cutoff used to prompt for the recommendation of prostate biopsy.

Methods: Between 2007 and 2013, 18 533 native Korean men eligible to receive a serum PSA test, liver profiles, and abdominal ultrasonography were recruited. Logistic regression was used to estimate the odds of an abnormal PSA (≥2.5 ng/mL) in these men (age 45-75 years, PSA≤10 ng/mL) in relation to FLD. The FLD status was categorized as normal, mild, moderate, and severe grade by abdominal sonography.

Results: A total of 16 563 men (89.4%) were included in the study after applying the inclusion criteria. Liver profiles were negatively correlated with the serum PSA level. After controlling for age and obesity, there was a statistically significant trend towards a lower likelihood of having a serum PSA level of ≥2.5 ng/mL with severe FLD, having a 34.7% lower likelihood (odds ratio 0.653, 95% confidence interval 0.477-0.88; p<0.01) compared to men in the normal group.

Conclusions: Severe FLD is an independent predictor of a lower likelihood of having abnormal PSA level. Further studies are needed to better define these results in clinical biopsy practice.