Mathematical model and its fast numerical method for the tumor growth

Math Biosci Eng. 2015 Dec;12(6):1173-87. doi: 10.3934/mbe.2015.12.1173.

Abstract

In this paper, we reformulate the diffuse interface model of the tumor growth (S.M. Wise et al., Three-dimensional multispecies nonlinear tumor growth-I: model and numerical method, J. Theor. Biol. 253 (2008) 524--543). In the new proposed model, we use the conservative second-order Allen--Cahn equation with a space--time dependent Lagrange multiplier instead of using the fourth-order Cahn--Hilliard equation in the original model. To numerically solve the new model, we apply a recently developed hybrid numerical method. We perform various numerical experiments. The computational results demonstrate that the new model is not only fast but also has a good feature such as distributing excess mass from the inside of tumor to its boundary regions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Cell Proliferation
  • Computer Simulation
  • Humans
  • Mathematical Concepts
  • Models, Biological*
  • Neoplasms / pathology*
  • Nonlinear Dynamics