Novel Composite Radiographic Score for Longitudinal Observational Studies of Psoriatic Arthritis: A Proof-of-concept Study

William Tillett; Gavin Shaddick; Deepak Jadon; Graham Robinson; Eleanor Korendowych; Neil McHugh

doi:10.3899/jrheum.150114

Novel Composite Radiographic Score for Longitudinal Observational Studies of Psoriatic Arthritis: A Proof-of-concept Study

J Rheumatol. 2016 Feb;43(2):367-70. doi: 10.3899/jrheum.150114. Epub 2016 Jan 15.

Authors

William Tillett¹, Gavin Shaddick², Deepak Jadon², Graham Robinson², Eleanor Korendowych², Neil McHugh²

Affiliations

¹ From the Royal National Hospital for Rheumatic Diseases; Department of Mathematics, University of Bath; Department of Pharmacy and Pharmacology, University of Bath; Department of Radiology, Royal United Hospital, Bath, UK.W. Tillett, BSc, MBChB, PhD, MRCP, Royal National Hospital for Rheumatic Diseases; G. Shaddick, MSc, PhD, Department of Mathematics, University of Bath; D. Jadon, MBBCh, MRCP, Royal National Hospital for Rheumatic Diseases; G. Robinson, MBBS, FRCR, Department of Radiology, Royal United Hospital; E. Korendowych, PhD, MRCP, Royal National Hospital for Rheumatic Diseases; N. McHugh, MB, ChB, MD, FRCP, Department of Pharmacy and Pharmacology, University of Bath. w.tillett@nhs.net.
² From the Royal National Hospital for Rheumatic Diseases; Department of Mathematics, University of Bath; Department of Pharmacy and Pharmacology, University of Bath; Department of Radiology, Royal United Hospital, Bath, UK.W. Tillett, BSc, MBChB, PhD, MRCP, Royal National Hospital for Rheumatic Diseases; G. Shaddick, MSc, PhD, Department of Mathematics, University of Bath; D. Jadon, MBBCh, MRCP, Royal National Hospital for Rheumatic Diseases; G. Robinson, MBBS, FRCR, Department of Radiology, Royal United Hospital; E. Korendowych, PhD, MRCP, Royal National Hospital for Rheumatic Diseases; N. McHugh, MB, ChB, MD, FRCP, Department of Pharmacy and Pharmacology, University of Bath.

PMID: 26773116
DOI: 10.3899/jrheum.150114

Abstract

Objective: To devise a feasible composite radiographic score for use in observational studies of psoriatic arthritis (PsA).

Methods: Radiographs from 50 patients with PsA were evaluated with the PsA-modified Sharp, Sharp/van der Heijde (SvdH), and Ratingen scores. Data reductions were made to devise a concise score.

Results: The Reductive X-ray Score for Psoriatic Arthritis (ReXSPA) required the assessment of only 22 joints (117 points), including erosion, joint space narrowing, and osteoproliferation in the hands and feet. The ReXSPA accounted for 80% of change detected with the SvdH score.

Conclusion: We report a proof-of-concept radiographic score for observational studies derived though data reduction.

Keywords: OUTCOME ASSESSMENT; PSORIATIC ARTHRITIS; RADIOGRAPHY.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Arthritis, Psoriatic / diagnostic imaging*
Disease Progression
Female
Hand Joints / diagnostic imaging*
Humans
Longitudinal Studies
Male
Middle Aged
Severity of Illness Index