Abstract
A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.
© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics*
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Chromatin Assembly and Disassembly / genetics
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Co-Repressor Proteins
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DNA Helicases / genetics*
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Genome, Human
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Heterochromatin / genetics*
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Histone-Lysine N-Methyltransferase / genetics
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Histones / genetics*
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Humans
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Molecular Chaperones / genetics
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Multiprotein Complexes / genetics
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Nuclear Proteins / genetics*
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X-linked Nuclear Protein
Substances
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Adaptor Proteins, Signal Transducing
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Co-Repressor Proteins
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DAXX protein, human
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Heterochromatin
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Histones
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Molecular Chaperones
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Multiprotein Complexes
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Nuclear Proteins
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Histone-Lysine N-Methyltransferase
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DNA Helicases
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ATRX protein, human
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X-linked Nuclear Protein