Thymoma is a kind of epithelial tumor of the thymus which about 30-50% patients accompanied by paraneoplastic disorders. However, the coexistence of seven symptoms in an individual is rare. This report represented a patient, diagnosed of thymoma, with myasthenia gravis, erythema multiforme, plasma cell cheilitis, recurrent oral ulcer, vitiligo, Raynaud's phenomenon and fissured tongue. Detailed clinical manifestations, serum immune biomarkers, imaging study, electrophysiology examination and pathology results are described in this case.
Keywords: Raynaud’s phenomenon; Thymoma; erythema multiforme; fissured tongue; myasthenia gravis; paraneoplastic syndromes; plasma cell cheilitis; recurrent oral ulcer; vitiligo.