Bioorthogonal Click Chemistry-Based Synthetic Cell Glue

Small. 2015 Dec 22;11(48):6458-66. doi: 10.1002/smll.201502972. Epub 2015 Nov 19.

Abstract

Artificial methods of cell adhesion can be effective in building functional cell complexes in vitro, but methods for in vivo use are currently lacking. Here, a chemical cell glue based on bioorthogonal click chemistry with high stability and robustness is introduced. Tetrazine (Tz) and trans-cyclooctene (TCO) conjugated to the cell surface form covalent bonds between cells within 10 min in aqueous conditions. Glued, homogeneous, or heterogeneous cell pairs remain viable and stably attached in a microfluidic flow channel at a shear stress of 20 dyn cm(-2) . Upon intravenous injection of assembled Jurkat T cells into live mice, fluorescence microscopy shows the trafficking of cell pairs in circulation and their infiltration into lung tissues. These results demonstrate the promising potential of chemically glued cell pairs for various applications ranging from delivering therapeutic cells to studying cell-cell interactions in vivo.

Keywords: cell adhesion; cell delivery; click chemistry; metabolic glycoengineering; tissue engineering.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adhesives / pharmacology*
  • Animals
  • Blood Circulation / drug effects
  • Cell Adhesion / drug effects
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Cell Survival
  • Click Chemistry / methods*
  • Flow Cytometry
  • High-Throughput Screening Assays
  • Humans
  • Interleukin-2 / metabolism
  • Metabolic Engineering
  • Mice
  • Mice, Inbred C57BL
  • Microfluidics
  • NIH 3T3 Cells

Substances

  • Adhesives
  • Interleukin-2