The real-life value of ST2 monitoring during heart failure decompensation: impact on long-term readmission and mortality

Biomarkers. 2016;21(3):225-32. doi: 10.3109/1354750X.2015.1130747. Epub 2016 Jan 15.

Abstract

Context: Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements.

Objective: The objective of this study is to investigate the prognostic value of ST2 in AHF.

Methods: ST2 levels were determined at admission (n = 182) and discharge (n = 85). Primary endpoint was the composite of all-cause death and HF rehospitalisation at one year.

Results: Discharge ST2 (HR 2.42 [95% CI 1.46-4], p = 0.001) and ΔST2 (HR 2.32 [95% CI 1.21-4.57], p = 0.01) but not admission ST2, remained independently prognostic for the primary endpoint after comprehensive multivariable adjustment. ST2 significantly improved prognosis stratification on top of clinical variables and NTproBNP.

Conclusions: Routine clinical use of discharge ST2 and ST2 dynamics provide independent prognostic information.

Keywords: Acute heart failure; ST2; biomarkers; outcomes; prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood*
  • Female
  • Heart Failure / blood*
  • Heart Failure / epidemiology
  • Heart Failure / physiopathology
  • Hospitalization
  • Humans
  • Interleukin-1 Receptor-Like 1 Protein / blood*
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain / blood*
  • Patient Discharge
  • Peptide Fragments / blood*
  • Prognosis
  • Risk Factors

Substances

  • Biomarkers
  • IL1RL1 protein, human
  • Interleukin-1 Receptor-Like 1 Protein
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain