Cybernetics, Redux: An Outside-In Strategy for Unraveling Cellular Function

Mohan Malleshaiah; Jeremy Gunawardena

doi:10.1016/j.devcel.2015.12.025

Cybernetics, Redux: An Outside-In Strategy for Unraveling Cellular Function

Dev Cell. 2016 Jan 11;36(1):2-4. doi: 10.1016/j.devcel.2015.12.025.

Authors

Mohan Malleshaiah¹, Jeremy Gunawardena²

Affiliations

¹ Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
² Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jeremy_gunawardena@hms.harvard.edu.

PMID: 26766437
DOI: 10.1016/j.devcel.2015.12.025

Abstract

A new paper in Science reveals how repetitive stimulation can identify and help to repair fragilities within a signaling network, while using linear mathematical models inspired by engineering, thereby suggesting how cybernetic methods can be integrated into systems and synthetic biology.

Publication types

Comment

MeSH terms

Mitogen-Activated Protein Kinases / metabolism*
Osmotic Pressure*
Saccharomyces cerevisiae / physiology*
Saccharomyces cerevisiae Proteins / metabolism*

Substances

Saccharomyces cerevisiae Proteins
Mitogen-Activated Protein Kinases