Evaluation of anticoagulant effects of direct thrombin inhibitors, dabigatran and argatroban, based on the Lineweaver-Burk plot applied to the Clauss assay

J Clin Pathol. 2016 Apr;69(4):370-2. doi: 10.1136/jclinpath-2015-203533. Epub 2016 Jan 11.

Authors

Yuta Fujimori¹, Masatoshi Wakui², Hisako Katagiri¹, Kentaro Ohira¹, Nobuko Shimizu¹, Mitsuru Murata²

Affiliations

¹ Central Clinical Laboratory, Keio University Hospital, Tokyo, Japan.
² Department of Laboratory Medicine, School of Medicine, Keio University, Tokyo, Japan.

PMID: 26754829
DOI: 10.1136/jclinpath-2015-203533

No abstract available

Keywords: ANTICOAGULANTS; CLOTTING; COAGULATION; FIBRINOGEN.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antithrombins / pharmacokinetics*
Arginine / analogs & derivatives
Blood Coagulation / drug effects*
Dabigatran / pharmacology*
Humans
Kinetics
Pipecolic Acids / pharmacology*
Sulfonamides

Substances

Antithrombins
Pipecolic Acids
Sulfonamides
Arginine
Dabigatran
argatroban