Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng

Kai Liu; Ya-Bin Yang; Jin-Lian Chen; Cui-Ping Miao; Qiang Wang; Hao Zhou; You-Wei Chen; Yi-Qing Li; Zhong-Tao Ding; Li-Xing Zhao

doi:10.1007/s13659-015-0085-z

Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng

Nat Prod Bioprospect. 2016 Feb;6(1):49-55. doi: 10.1007/s13659-015-0085-z. Epub 2016 Jan 11.

Authors

Kai Liu¹, Ya-Bin Yang², Jin-Lian Chen³, Cui-Ping Miao¹, Qiang Wang¹, Hao Zhou², You-Wei Chen¹, Yi-Qing Li¹, Zhong-Tao Ding⁴, Li-Xing Zhao⁵

Affiliations

¹ Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, People's Republic of China.
² Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
³ School of Energy and Environment Science, Yunnan Normal University, Kunming, 650092, People's Republic of China.
⁴ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. ztding@ynu.edu.cn.
⁵ Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, People's Republic of China. zlx70@163.com.

Abstract

Four new fungal polyketides named koninginins N-Q (1-4), together with four known analogues (5-8), were isolated from the endophytic fungus Trichoderma koningiopsis YIM PH30002 harbored in Panax notoginseng. Their structures were determined on the basis of spectral data interpretation. These compounds were evaluated for their antifungal activity, nitric oxide inhibition, and anticoagulant activity.

Keywords: Antifungal activity; Bioactivity assay; Koninginin; Polyketide; Trichoderma koningiopsis.