Abstract
Although mammals are notoriously poor at regeneration compared with many lower-order species, the hair follicle, particular to mammals, is capable of regeneration following partial amputation. The detailed internal mechanism of this phenomenon is still unclear. Development and regrowth of the hair follicle depends on dermal-epidermal interaction within the hair follicle. Previous studies have shown that Wnt/β-catenin, Shh, Bmp, PDGF, TGF and Notch signals all take part in the development and growth of the hair follicle, and the Wnt/β-catenin signaling additionally plays an indispensable role in hair follicle morphogenesis and regrowth. In this study, we investigated the localization, as well as, protein levels of Wnt/β-catenin signaling molecules during amputated whisker follicle regeneration.
Keywords:
Differentiation; Hair follicle; Immunofluorescence staining; Regeneration; Stem cell; Wnt/β-catenin signaling.
MeSH terms
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Animals
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Bone Morphogenetic Protein 1 / genetics
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Bone Morphogenetic Protein 1 / metabolism
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Bone Morphogenetic Protein Receptors / genetics
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Bone Morphogenetic Protein Receptors / metabolism
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Dermis / metabolism
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Dermis / transplantation*
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Dissection
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Female
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Gene Expression Regulation*
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Hair Follicle / metabolism
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Hair Follicle / transplantation*
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Hedgehog Proteins / genetics
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Hedgehog Proteins / metabolism
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Mice
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Mice, Nude
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Platelet-Derived Growth Factor / genetics
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Platelet-Derived Growth Factor / metabolism
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Rats
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Rats, Sprague-Dawley
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Receptors, Notch / genetics
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Receptors, Notch / metabolism
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Regeneration / genetics*
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Vibrissae / metabolism
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Vibrissae / transplantation*
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Wnt Proteins / genetics
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Wnt Proteins / metabolism
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Wnt Signaling Pathway / genetics*
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beta Catenin / genetics
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beta Catenin / metabolism
Substances
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Hedgehog Proteins
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Platelet-Derived Growth Factor
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Receptors, Notch
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Shh protein, rat
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Wnt Proteins
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beta Catenin
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Bone Morphogenetic Protein Receptors
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Bmp1 protein, mouse
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Bone Morphogenetic Protein 1