Cardiomyocyte Autophagia and Morphological Alterations in the Left Ventricular Myocardium during Acute Focal Ischemia

M L Blagonravov; A Yu Korshunova; M M Azova; S A Bondar'; V A Frolov

doi:10.1007/s10517-016-3180-1

Cardiomyocyte Autophagia and Morphological Alterations in the Left Ventricular Myocardium during Acute Focal Ischemia

Bull Exp Biol Med. 2016 Jan;160(3):398-400. doi: 10.1007/s10517-016-3180-1. Epub 2016 Jan 8.

Authors

M L Blagonravov¹, A Yu Korshunova², M M Azova³, S A Bondar'², V A Frolov²

Affiliations

¹ Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship, Moscow, Russia. blagonravovm@mail.ru.
² Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship, Moscow, Russia.
³ Department of Biology and General Genetics, Medical Institute of Russian University of People Friendship, Moscow, Russia.

PMID: 26742735
DOI: 10.1007/s10517-016-3180-1

Abstract

In experiments on rabbits we evaluated the intensity of cardiomyocyte autophagia by the level beclin-1 protein and morphology of the left ventricular myocardium on days 1, 3, and 5 after the onset of focal ischemia caused by ligation of the descending branch of the left coronary artery. The morphological alterations in the left ventricular myocardium were accompanied by intensification of cardiomyocyte autophagia, which attained maximum on postligation day 1.

Keywords: autophagia; beclin-1; cardiomyocyte; focal ischemia; myocardium.

MeSH terms

Animals
Apoptosis Regulatory Proteins / metabolism
Autophagy / physiology
Male
Myocardial Ischemia / metabolism
Myocardial Ischemia / pathology*
Myocytes, Cardiac / metabolism
Myocytes, Cardiac / pathology
Rabbits
Ventricular Function, Left / physiology

Substances

Apoptosis Regulatory Proteins