Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

Gautier M A Ndong Ntoutoume; Robert Granet; Jean Pierre Mbakidi; Frédérique Brégier; David Y Léger; Chloë Fidanzi-Dugas; Vincent Lequart; Nicolas Joly; Bertrand Liagre; Vincent Chaleix; Vincent Sol

doi:10.1016/j.bmcl.2015.12.060

Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

Bioorg Med Chem Lett. 2016 Feb 1;26(3):941-945. doi: 10.1016/j.bmcl.2015.12.060. Epub 2015 Dec 18.

Affiliations

¹ Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
² Université d'Artois, IUT de Béthune, 1230 rue de l'Université, 62408 Béthune Cedex, France.
³ Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France. Electronic address: vincent.sol@unilim.fr.

PMID: 26739777
DOI: 10.1016/j.bmcl.2015.12.060

Abstract

The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.

Keywords: Cancer cells; Cellulose nanocrystals; Curcumin; Drug delivery; Nanoparticles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Cell Proliferation / drug effects
Cellulose / chemistry*
Curcumin / chemistry*
Curcumin / toxicity
Drug Carriers / chemistry
HT29 Cells
Humans
Microscopy, Confocal
Nanoparticles / chemistry*
beta-Cyclodextrins / chemistry*

Substances

Drug Carriers
beta-Cyclodextrins
Cellulose
Curcumin
betadex