3D axonal network coupled to Microelectrode Arrays: A simulation model to study neuronal dynamics

Revathi Appali; Kiran K Sriperumbudur; Ursula van Rienen

doi:10.1109/EMBC.2015.7319443

3D axonal network coupled to Microelectrode Arrays: A simulation model to study neuronal dynamics

Annu Int Conf IEEE Eng Med Biol Soc. 2015:2015:4700-4. doi: 10.1109/EMBC.2015.7319443.

Authors

Revathi Appali, Kiran K Sriperumbudur, Ursula van Rienen

PMID: 26737343
DOI: 10.1109/EMBC.2015.7319443

Abstract

Action Potentials in a neuron are generated and propagated by exchange of ions through the membrane. The model of Hodgkin and Huxley (HH) describes these time-dependent complex ion dynamics. We have implemented the FitzHugh-Nagumo model, one of the simplified versions of HH model on a pyramidal neuron with branches of axons to study the spontaneous activity of neurons. The network is then coupled to Micro-Electrode Arrays to record the extracellular potential in a neurochip environment. This in silico model is used to study the coupling of AP with the electrodes. Such a model is also a first step to investigate the morphological influence of neurons on their signaling properties.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Action Potentials / physiology
Axons / physiology
Finite Element Analysis
Microelectrodes
Models, Neurological*
Pyramidal Cells / physiology*