Upcoming innovations in lung cancer immunotherapy: focus on immune checkpoint inhibitors

Chin Clin Oncol. 2015 Dec;4(4):48. doi: 10.3978/j.issn.2304-3865.2015.12.06.

Abstract

For decades, immunotherapy strategies have failed to succeed in lung cancer. However, the recent success of immune checkpoint inhibitors and the progress in the understanding of the immunobiology of lung cancer have changed this paradigm. Here we review ongoing clinical trials and recent results obtained with these novel lung cancer immunotherapies.

Keywords: Immune checkpoint inhibitors; immunotherapy; lung cancer; vaccines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use*
  • Cancer Vaccines / adverse effects
  • Cancer Vaccines / therapeutic use*
  • Humans
  • Immunologic Factors / adverse effects
  • Immunologic Factors / therapeutic use*
  • Immunotherapy / adverse effects
  • Immunotherapy / methods*
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / immunology
  • Lung Neoplasms / pathology
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Cancer Vaccines
  • Immunologic Factors