Abstract
Objectives:
To investigate if fluoroquinolones (FQs) influence skeletal muscle metabolism of healthy and malignant hyperthermia susceptible (MHS) pigs.
Materials and methods:
After approval from of the Animal Care Committee, 10 MHS pigs, and 6 MHS pigs were anesthetized with hemodynamic and systemic metabolic monitoring. Microdialysis catheters were placed intramuscularly. After equilibration, levofloxacin and ciprofloxacin were injected as a rapid bolus and continuous infusions. Lactate was measured in the dialysate and statistically analyzed was done (Wilcoxon-test; U-test; P < 0.05).
Results:
There were no differences in age, weight, and baseline lactate levels between the groups. Both applications of levofloxacin- and ciprofloxacin-induced an increase of local lactate levels in healthy and MHS pigs. No difference between the two groups was observed.
Conclusion:
FQs influence skeletal muscle metabolism. Myotoxic effects of FQs can, therefore, be explained by an influence on the cellular energy balance.
Keywords:
Fluoroquinolones; malignant hyperthermia; metabolism; myotoxicity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Inbred Strains
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / pharmacology*
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Belgium
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Ciprofloxacin / administration & dosage
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Ciprofloxacin / adverse effects*
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Disease Susceptibility
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Drug Resistance
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Energy Metabolism / drug effects*
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Fluoroquinolones / administration & dosage
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Fluoroquinolones / adverse effects
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Fluoroquinolones / pharmacology*
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Infusions, Intravenous
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Lactic Acid / blood
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Levofloxacin / administration & dosage
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Levofloxacin / adverse effects*
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Malignant Hyperthermia / blood
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Malignant Hyperthermia / metabolism
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Malignant Hyperthermia / veterinary
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Microdialysis
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Muscle, Skeletal / drug effects*
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Muscle, Skeletal / metabolism
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Sus scrofa
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Swine
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Swine Diseases / blood
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Swine Diseases / metabolism
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Topoisomerase II Inhibitors / administration & dosage
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Topoisomerase II Inhibitors / adverse effects
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Topoisomerase II Inhibitors / pharmacology*
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Up-Regulation / drug effects
Substances
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Anti-Bacterial Agents
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Fluoroquinolones
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Topoisomerase II Inhibitors
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Lactic Acid
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Ciprofloxacin
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Levofloxacin