Metabolic effects as a cause of myotoxic effects of fluoroquinolones

Indian J Pharmacol. 2015 Nov-Dec;47(6):616-9. doi: 10.4103/0253-7613.169571.

Abstract

Objectives: To investigate if fluoroquinolones (FQs) influence skeletal muscle metabolism of healthy and malignant hyperthermia susceptible (MHS) pigs.

Materials and methods: After approval from of the Animal Care Committee, 10 MHS pigs, and 6 MHS pigs were anesthetized with hemodynamic and systemic metabolic monitoring. Microdialysis catheters were placed intramuscularly. After equilibration, levofloxacin and ciprofloxacin were injected as a rapid bolus and continuous infusions. Lactate was measured in the dialysate and statistically analyzed was done (Wilcoxon-test; U-test; P < 0.05).

Results: There were no differences in age, weight, and baseline lactate levels between the groups. Both applications of levofloxacin- and ciprofloxacin-induced an increase of local lactate levels in healthy and MHS pigs. No difference between the two groups was observed.

Conclusion: FQs influence skeletal muscle metabolism. Myotoxic effects of FQs can, therefore, be explained by an influence on the cellular energy balance.

Keywords: Fluoroquinolones; malignant hyperthermia; metabolism; myotoxicity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Inbred Strains
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / pharmacology*
  • Belgium
  • Ciprofloxacin / administration & dosage
  • Ciprofloxacin / adverse effects*
  • Disease Susceptibility
  • Drug Resistance
  • Energy Metabolism / drug effects*
  • Fluoroquinolones / administration & dosage
  • Fluoroquinolones / adverse effects
  • Fluoroquinolones / pharmacology*
  • Infusions, Intravenous
  • Lactic Acid / blood
  • Levofloxacin / administration & dosage
  • Levofloxacin / adverse effects*
  • Malignant Hyperthermia / blood
  • Malignant Hyperthermia / metabolism
  • Malignant Hyperthermia / veterinary
  • Microdialysis
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / metabolism
  • Sus scrofa
  • Swine
  • Swine Diseases / blood
  • Swine Diseases / metabolism
  • Topoisomerase II Inhibitors / administration & dosage
  • Topoisomerase II Inhibitors / adverse effects
  • Topoisomerase II Inhibitors / pharmacology*
  • Up-Regulation / drug effects

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones
  • Topoisomerase II Inhibitors
  • Lactic Acid
  • Ciprofloxacin
  • Levofloxacin