New Iridoid Glycosides with Antidepressant Activity Isolated from Cyperus rotundus

Chem Pharm Bull (Tokyo). 2016;64(1):73-7. doi: 10.1248/cpb.c15-00686.

Abstract

Based on bioactive screening results, two new iridoid glycosides, named rotunduside G (1) and rotunduside H (2), were isolated from the rhizomes of Cyperus rotundus, together with four known ones, negundoside (3), nishindaside (4), isooleuropein (5) and neonuezhenide (6). Their structures were elucidated on the basis of spectroscopic methods and from literature values. In mice models of despair, 1 and 2 showed significant antidepressant activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antidepressive Agents / chemistry
  • Antidepressive Agents / isolation & purification
  • Antidepressive Agents / pharmacology*
  • Behavior, Animal / drug effects*
  • Cyperus / chemistry*
  • Hindlimb Suspension
  • Iridoid Glycosides / chemistry
  • Iridoid Glycosides / isolation & purification
  • Iridoid Glycosides / pharmacology*
  • Male
  • Mice
  • Molecular Structure
  • Motor Activity / drug effects*
  • Swimming

Substances

  • Antidepressive Agents
  • Iridoid Glycosides