Tenogenic differentiation of mesenchymal stem cells and noncoding RNA: From bench to bedside

Ying-fei Lu; Kai-ming Chan; Gang Li; Jin-fang Zhang

doi:10.1016/j.yexcr.2015.12.014

Tenogenic differentiation of mesenchymal stem cells and noncoding RNA: From bench to bedside

Exp Cell Res. 2016 Feb 15;341(2):237-42. doi: 10.1016/j.yexcr.2015.12.014. Epub 2015 Dec 24.

Authors

Ying-fei Lu¹, Kai-ming Chan², Gang Li³, Jin-fang Zhang⁴

Affiliations

¹ Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China; Lui Che Woo Institute of Innovative Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
² Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China; Lui Che Woo Institute of Innovative Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
³ Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China; Lui Che Woo Institute of Innovative Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: gangli@cuhk.edu.hk.
⁴ Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China; Lui Che Woo Institute of Innovative Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: zhangjf06@cuhk.edu.hk.

PMID: 26724570
DOI: 10.1016/j.yexcr.2015.12.014

Abstract

Tendon is a critical unit of musculoskeletal system that connects muscle to bone to control bone movement. More population participate in physical activities, tendon injuries, such as acute tendon rupture and tendinopathy due to overuse, are common causing unbearable pain and disability. However, the process of tendon development and the pathogenesis of tendinopathy are not well defined, limiting the development of clinical therapy for tendon injuries. Studying the tendon differentiation control pathways may help to develop novel therapeutic strategies. This review summarized the novel molecular and cellular events in tendon development and highlighted the clinical application potential of non-coding RNAs and tendon-derived stem cells in gene and cell therapy for tendon injuries, which may bring insights into research and new therapy for tendon disorders.

Keywords: Non-coding RNAs; Tendon; Tendon differentiation; Tendon-derived stem cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation / physiology*
Cell- and Tissue-Based Therapy / methods
Humans
Mesenchymal Stem Cells / cytology*
RNA, Untranslated / genetics*
Stem Cells / cytology*
Tendon Injuries / therapy*

Substances

RNA, Untranslated