Drug therapy is essential for cancer treatment. The molecular targeted anticancer drugs develop rapidly in recent years, since the effectiveness of traditional chemotherapy is unsatisfactory and the adverse reactions are high. However, molecular targeted anticancer drugs would damage the function of heart, liver or lung, and may cause adverse effects such as hand-foot syndrome, which restrains their clinical application. Therefore, it is critical for pharmaceutical toxicology to study the toxicity, the related mechanisms and the preventive measures of molecular targeted anticancer drugs.
：药物治疗是肿瘤治疗的重要手段, 传统的化疗药物疗效欠佳、副作用大, 因此以酪氨酸激酶抑制剂为代表的分子靶向抗肿瘤药物得到大力发展。分子靶向抗肿瘤药物具有靶向性强、疗效显著等特点, 但在临床应用的过程中会对心、肝、肺等重要脏器造成不同程度的损伤以及引发手足综合征等不良反应, 极大地限制其在临床的应用和发展。因此, 分析分子靶向抗肿瘤药物的毒性反应临床现状, 研究其作用机制及保护干预措施已成为药物毒理学研究的重要任务。