Bromotyrosine-derived metabolites from an Indonesian marine sponge in the family Aplysinellidae (Order Verongiida)

Bioorg Med Chem Lett. 2016 Jan 15;26(2):499-504. doi: 10.1016/j.bmcl.2015.11.086. Epub 2015 Nov 25.

Abstract

Seven new bromotyrosine-derived metabolites, purpuramine M-N (1-2), araplysillin VII-XI (3-7) and six known compounds (8-13) were isolated from an Indonesian sponge belonging to the family Aplysinellidae (Order Verongiida). The structures of the new compounds were determined by extensive NMR experiments and mass spectrometric measurements. These compounds were screened against BACE1 and five cancer cell lines.

Keywords: Aplysinellidae; BACE1 inhibitors; Bromotyrosine-derivatives; Cell viability; Verongiida.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amyloid Precursor Protein Secretases / antagonists & inhibitors
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Aspartic Acid Endopeptidases / antagonists & inhibitors*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Humans
  • Isoxazoles / chemistry
  • Isoxazoles / isolation & purification
  • Isoxazoles / pharmacology
  • Mice
  • NIH 3T3 Cells
  • Oximes / chemistry
  • Oximes / isolation & purification
  • Oximes / pharmacology
  • Porifera / chemistry*
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / isolation & purification
  • Protease Inhibitors / pharmacology*
  • Tyrosine / analogs & derivatives*
  • Tyrosine / chemistry
  • Tyrosine / isolation & purification
  • Tyrosine / pharmacology*

Substances

  • Antineoplastic Agents
  • Isoxazoles
  • Oximes
  • Protease Inhibitors
  • Tyrosine
  • Amyloid Precursor Protein Secretases
  • Aspartic Acid Endopeptidases