Abstract
An efficient Pd(II)-catalyzed approach for the direct synthesis of indolo[3,2-a]pyrrolo[3,4-c]carbazole-6,8-diones has been developed from both free and protected (NH) indoles and maleimides via a regioselective tandem oxidative coupling reaction. The yields are moderate to excellent. In addition, 2-substituted indoles are suitable substrates in this protocol, leading to the formation of indolylmaleimides. The present methodology provides a concise route to highly functionalized indolopyrrolocarbazole derivatives.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbazoles / chemical synthesis*
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Carbazoles / chemistry
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Catalysis
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Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Indoles / chemical synthesis*
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Indoles / chemistry
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Maleimides / chemical synthesis
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Maleimides / chemistry*
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Molecular Structure
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Oxidative Coupling
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Palladium / chemistry*
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Stereoisomerism
Substances
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Carbazoles
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Heterocyclic Compounds, 4 or More Rings
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Indoles
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Maleimides
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Palladium