Abstract
Phytochemical investigation on the aqueous extract from Dryopteris fragrans led to the isolation of one new chromone glycoside, frachromone C (1), and one new coumarin glycoside, dryofracoulin A (2), together with one known undulatoside A (3). Their structures were elucidated by a combination of 1D and 2D NMR, HRMS, and chemical analysis. Compounds 1-3 exhibited inhibition on nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages with their IC50 values of 45.8, 65.8, and 49.8 μM, respectively.
Keywords:
Dryopteridaceae; Dryopteris fragrans; anti-inflammatory activity; isolation; structure elucidation.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / isolation & purification*
-
Anti-Inflammatory Agents / pharmacology*
-
Chromones
-
Coumarins / chemistry
-
Coumarins / isolation & purification*
-
Coumarins / pharmacology*
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology*
-
Dryopteris / chemistry*
-
Glycosides / chemistry
-
Glycosides / isolation & purification*
-
Glycosides / pharmacology*
-
Lipopolysaccharides / pharmacology
-
Macrophages / drug effects
-
Mice
-
Molecular Structure
-
Nitric Oxide / biosynthesis
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Extracts / chemistry
Substances
-
Anti-Inflammatory Agents
-
Chromones
-
Coumarins
-
Drugs, Chinese Herbal
-
Glycosides
-
Lipopolysaccharides
-
Plant Extracts
-
dryofracoulin A
-
frachromone C
-
Nitric Oxide