Background and objectives: There is only limited available evidence of a relationship between total plasma homocysteine (tHcy) levels and type 2 diabetes in hypertensive subjects.
Methods and study design: A total of 5,935 Chinese essentially hypertensive subjects were recruited by cluster sampling from 60 communities. The cases had diabetes, whereas the controls did not. Anthropometric indices and biochemical parameters were assessed using standard procedures. A multivariable analysis was performed to analyze the association of tHcy and type 2 diabetes susceptibility in hypertensive subjects.
Results: The 5,241 controls (women/men: 2,716/2,625) and 594 cases (women/men: 291/303) were recruited consecutively. The level of tHcy was dose- dependently associated with type 2 diabetes in the hypertensive women subjects. After controlling for corresponding confounding factors, a significant trend was only noted in the women subjects, with odds ratios per 5 μmol/L tHcy of 1.11 (95% confidence interval (CI), 1.07-1.16) in the crude model, 1.05 (95% CI, 1.01-1.11) in model 1, and 1.07 (95% CI, 1.02-1.13) in model 2. However, no significant result was found for levels of tHcy>or=15 μmol/L vs <15 μmol/L in the men, women and all hypertensive subjects.
Conclusions: When the level of tHcy was divided into quartiles, tHcy was positively associated with type 2 diabetes in hypertensive women subjects. However, when the level of tHcy was separated into hyperhomocysteinemic (>or=15 μmol/L) and normal (<15 μmol/L), no significant results were observed.
背景与目的：在高血压患者中针对同型半胱氨酸水平与2 型糖尿病之间关系的 研究较少。方法与研究设计：该研究对深圳市南山区60 个社区的5935 名原发 性高血压患者进行了调查。病例组为高血压患者伴发糖尿病，对照组为高血压 患者无糖尿病。采用标准方法对其人口学特征及生化指标进行调查。采用多变 量分析方法分析同型半胱氨酸水平与2 型糖尿病的关系。结果：该研究一共纳 入5241 例对照（男/女：2716/2625）与594 例病例（男/女：291/303）。在女 性高血压患者中，同型半胱氨酸水平与2 型糖尿病之间呈剂量反应关系。在控 制了相应的混杂因素之后，同型半胱氨酸水平每升高5 μmol/L，在原始模型 中，比值比及95%可信区间为1.11 (1.07-1.16)，在模型1 中，比值比及95% 可信区间为1.05 (1.01-1.11)，在模型2 中，比值比及95%可信区间为1.07 (1.02-1.13)。在高血压患者中，未发现高Hcy 血症分级(>=15 μmol/L vs <15 μmol/L)与2 型糖尿病存在关联。结论：当将同型半胱氨酸水平按照四分位数 进行分级时，女性高血压患者同型半胱氨酸水平与2 型糖尿病之间存在关联。 然而并未发现高Hcy 血症分级(>=15 μmol/L vs <15 μmol/L)与2 型糖尿病存在关 联。.