Inflammation and cutaneous nervous system involvement in hypertrophic scarring

Shao-Hua Li; Heng-Lian Yang; Hu Xiao; Yi-Bing Wang; De-Chang Wang; Ran Huo

doi:10.4103/1673-5374.167769

Inflammation and cutaneous nervous system involvement in hypertrophic scarring

Neural Regen Res. 2015 Oct;10(10):1678-82. doi: 10.4103/1673-5374.167769.

Authors

Shao-Hua Li¹, Heng-Lian Yang², Hu Xiao¹, Yi-Bing Wang¹, De-Chang Wang¹, Ran Huo¹

Affiliations

¹ Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
² Jinan Fire Protection Hospital, Jinan, Shandong Province, China.

Abstract

This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation.

Keywords: hypertrophic scar; interleukin-13; nerve growth factor; nerve regeneration; neural regeneration; peripheral nerve regeneration; wound healing.