Transforming the recognition site of 4-hydroxyaniline into 4-methoxyaniline grafted onto a BODIPY core switches the selective detection of peroxynitrite to hypochlorous acid

Chunchang Zhao; Jiancai An; Li Zhou; Qiang Fei; Feiyi Wang; Jie Tan; Ben Shi; Rui Wang; Zhiqian Guo; Wei-Hong Zhu

doi:10.1039/c5cc08936k

Transforming the recognition site of 4-hydroxyaniline into 4-methoxyaniline grafted onto a BODIPY core switches the selective detection of peroxynitrite to hypochlorous acid

Chem Commun (Camb). 2016 Feb 4;52(10):2075-8. doi: 10.1039/c5cc08936k.

Authors

Chunchang Zhao¹, Jiancai An¹, Li Zhou², Qiang Fei¹, Feiyi Wang¹, Jie Tan¹, Ben Shi¹, Rui Wang², Zhiqian Guo¹, Wei-Hong Zhu¹

Affiliations

¹ Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science & Technology, Shanghai 200237, P. R. China. zhaocchang@ecust.edu.cn.
² Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, P. R. China. ruiwang@ecust.edu.cn.

PMID: 26688579
DOI: 10.1039/c5cc08936k

Abstract

Two novel probes were designed, sharing the same BODIPY core but differing only by a minimized variation in the recognition site from 4-hydroxyaniline into 4-methoxyaniline. Such a small change in the reaction site could switch the selective detection from peroxynitrite to HOCl. Undoubtedly, the new designed BODIPY core exhibits valuable properties.

Publication types

Research Support, Non-U.S. Gov't