Drug the Bug!

Annika Lindskog Jonsson; Fredrik Bäckhed

doi:10.1016/j.cell.2015.12.005

Drug the Bug!

Cell. 2015 Dec 17;163(7):1565-6. doi: 10.1016/j.cell.2015.12.005.

Authors

Annika Lindskog Jonsson¹, Fredrik Bäckhed²

Affiliations

¹ The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg SE-413 45, Sweden.
² The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg SE-413 45, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address: fredrik.backhed@wlab.gu.se.

PMID: 26687345
DOI: 10.1016/j.cell.2015.12.005

Abstract

Microbial metabolism of dietary components has been causally linked to cardiovascular disease and atherosclerosis. Now, Wang et al. demonstrate that inhibition of microbial TMA lyases, essential for production of pro-atherogenic trimethylamines, prevents atherosclerosis in vivo.

Publication types

Comment

MeSH terms

Animals
Atherosclerosis / drug therapy*
Choline / analogs & derivatives*
Gastrointestinal Tract / microbiology*
Hexanols / administration & dosage*
Humans
Lyases / antagonists & inhibitors*
Methylamines / metabolism*

Substances

Hexanols
Methylamines
Lyases
Choline