Correlation of bone marrow abnormalities, peripheral lymphocyte subsets and clinical features in uncomplicated common variable immunodeficiency (CVID) patients

Clin Immunol. 2016 Feb:163:10-3. doi: 10.1016/j.clim.2015.12.006. Epub 2015 Dec 11.

Abstract

B cell developmental defects in CVID were recently described in a limited number of cases. To date, a detailed correlation between this maturational defect and the clinical presentation of affected patients has not been reported. In this study, we correlated bone marrow B cell evaluation, peripheral B and T lymphocyte subsets and clinical findings in 15 CVID patients. Early B cell developmental defects were observed in one third of patients. Combined bone marrow and peripheral lymphocytes evaluation allowed to further subdivide CVID patients in three groups with shared clinical features at diagnosis and during follow-up. These data broaden the number of CVID patients with early B cell developmental defects and, together with the peripheral lymphocytes evaluation, offer insight into the related clinical features in affected patients.

Keywords: B cells; Bone marrow; CVID.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Autoimmune Diseases / etiology
  • Autoimmune Diseases / immunology
  • B-Lymphocyte Subsets / immunology
  • B-Lymphocytes / immunology*
  • Bone Marrow
  • Bone Marrow Cells / immunology*
  • Bronchiectasis / etiology
  • Bronchiectasis / immunology
  • Common Variable Immunodeficiency / complications
  • Common Variable Immunodeficiency / immunology*
  • Female
  • Flow Cytometry
  • Humans
  • Lymphocyte Activation / immunology*
  • Male
  • Middle Aged
  • Recurrence
  • Respiratory Tract Infections / etiology
  • Respiratory Tract Infections / immunology
  • Splenomegaly / etiology
  • Splenomegaly / immunology
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes / immunology*
  • Young Adult