Genetic polymorphisms and the development of invasive bacterial infections in children

Int J Immunopathol Pharmacol. 2016 Mar;29(1):99-104. doi: 10.1177/0394632015622961. Epub 2015 Dec 18.

Abstract

To evaluate the associations between single nucleotide polymorphisms (SNPs) of factors involved in the development of invasive bacterial disease (IBD) in children, 47 SNPs of 18 candidate genes were analysed in 49 children with IBD and 100 controls. The G/T genotype of TLR2 rs2149356 and the C genotype of LTA rs2229094 were associated with significantly reduced risk of developing IBD (P=0.04 and P=0.05, respectively), whereas the C/T genotype of RFP175 rs1585110 was associated with a significantly higher risk of developing IBD (P=0.02). These results support the evidence that some genetic variants of factors involved in innate immunity may influence IBD risk in children.

Keywords: Neisseria meningitidis; Streptococcus pneumoniae; adaptive immunity; genetic polymorphisms; innate immunity; invasive bacterial disease; sepsis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Bacterial Infections / etiology
  • Bacterial Infections / genetics*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immunity, Innate
  • Lymphotoxin-alpha / genetics
  • Male
  • Polymorphism, Single Nucleotide*
  • Prospective Studies
  • Toll-Like Receptor 2 / genetics
  • Toll-Like Receptor 4 / genetics

Substances

  • Lymphotoxin-alpha
  • TLR2 protein, human
  • TLR4 protein, human
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4