Differential Receptor for Advanced Glycation End Products Expression in Preeclamptic, Intrauterine Growth Restricted, and Gestational Diabetic Placentas

Am J Reprod Immunol. 2016 Feb;75(2):172-80. doi: 10.1111/aji.12462. Epub 2015 Dec 19.

Abstract

Problem: Receptor for advanced glycation end products (RAGE) is a receptor implicated in the modulation of inflammation. Inflammation has been associated with pregnancy pathologies including preeclampsia (PE), intrauterine growth restriction (IUGR), and gestational diabetes mellitus (GDM). Our objective was to examine placental RAGE expression in PE, IUGR, and GDM complications.

Method of study: Human placental tissues were obtained for RAGE determination using Q-PCR, immunohistochemistry, and Western blot. Invasive trophoblast cells were cultured and treated with AGES for RAGE activation studies.

Results: Compared to control placenta, we observed: (i) decreased RAGE gene expression during GDM, (ii) increased RAGE protein in the PE placenta, and (iii) decreased RAGE protein in the IUGR placenta. In trophoblast cells exposed AGEs, we observed: (i) decreased trophoblast invasion, (ii) increased c-Jun N-terminal kinases (JNK) and Extracellular signal-regulated kinases (ERK), and (iii) increased TNF-α and IL-1β secretion.

Conclusion: We conclude that placental RAGE is activated during PE and that RAGE-mediated inflammation in the trophoblast involves increased pro-inflammatory cytokine secretion.

Keywords: Diabetes Mellitus; intrauterine growth restriction; placenta; preeclampsia; receptors for advanced glycation end products.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Cell Line
  • Cell Movement / drug effects
  • Diabetes, Gestational / metabolism*
  • Extracellular Signal-Regulated MAP Kinases / metabolism
  • Female
  • Fetal Growth Retardation / metabolism*
  • Glycation End Products, Advanced / pharmacology
  • Humans
  • Interleukin-1beta / metabolism
  • JNK Mitogen-Activated Protein Kinases / metabolism
  • Placenta / metabolism
  • Pre-Eclampsia / metabolism*
  • Pregnancy
  • Receptor for Advanced Glycation End Products / genetics
  • Receptor for Advanced Glycation End Products / metabolism*
  • Trophoblasts / metabolism
  • Trophoblasts / physiology
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Glycation End Products, Advanced
  • Interleukin-1beta
  • Receptor for Advanced Glycation End Products
  • Tumor Necrosis Factor-alpha
  • Extracellular Signal-Regulated MAP Kinases
  • JNK Mitogen-Activated Protein Kinases