Risk Factors for Maternal Mortality in Rural Tigray, Northern Ethiopia: A Case-Control Study

PLoS One. 2015 Dec 17;10(12):e0144975. doi: 10.1371/journal.pone.0144975. eCollection 2015.

Abstract

Background: Maternal mortality continues to have devastating impacts in many societies, where it constitutes a leading cause of death, and thus remains a core issue in international development. Nevertheless, individual determinants of maternal mortality are often unclear and subject to local variation. This study aims to characterise individual risk factors for maternal mortality in Tigray, Ethiopia.

Methods: A community-based case-control study was conducted, with 62 cases and 248 controls from six randomly-selected rural districts. All maternal deaths between May 2012 and September 2013 were recruited as cases and a random sample of mothers who delivered in the same communities within the same time period were taken as controls. Multiple logistic regression was used to identify independent determinants of maternal mortality.

Results: Four independent individual risk factors, significantly associated with maternal death, emerged. Women who were not members of the voluntary Women's Development Army were more likely to experience maternal death (OR 2.07, 95% CI 1.04-4.11), as were women whose husbands or partners had below-median scores for involvement during pregnancy (OR 2.19, 95% CI 1.14-4.18). Women with a pre-existing history of other illness were also at increased risk (OR 5.58, 95% CI 2.17-14.30), as were those who had never used contraceptives (OR 2.58, 95% CI 1.37-4.85). Previous pregnancy complications, a below-median number of antenatal care visits and a woman's lack of involvement in health care decision making were significant bivariable risks that were not significant in the multivariable model.

Conclusions: The findings suggest that interventions aimed at reducing maternal mortality need to focus on encouraging membership of the Women's Development Army, enhancing husbands' involvement in maternal health services, improving linkages between maternity care and other disease-specific programmes and ensuring that women with previous illnesses or non-users of contraceptive services are identified and followed-up as being at increased risk during pregnancy and childbirth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Ethiopia / epidemiology
  • Female
  • Humans
  • Logistic Models
  • Maternal Health Services / statistics & numerical data
  • Maternal Mortality*
  • Middle Aged
  • Pregnancy
  • Pregnancy Complications / epidemiology
  • Risk Factors
  • Young Adult

Grants and funding

This work was primarily supported as part of the routine activities of the Tigray Regional Health Bureau. The authors thank the Swedish Research Council for Swedish Research Links collaboration grant C0615601 which facilitated external participation in this research.