Catalytic reductive N-alkylation of amines using carboxylic acids

Chem Commun (Camb). 2016 Jan 31;52(9):1855-8. doi: 10.1039/c5cc08881j.

Abstract

We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.