The current study aimed to investigate in vitro anthelmintic efficacy of two medicinally important plants against Haemonchus contortus in small ruminants. Fruit peel of Punica granatum Linn. (vern. Anar), leaves and roots of Berberis lycium Royle (vern. Sumbal) were tested for their anthelmintic efficacy. Methanolic extracts of the test plants from various plant parts were tested for anthelmintic efficacy against the Haemonchus contortous using albendazole as a reference standard. The results revealed that both the plant extracts exhibited potent anthelmintic activity at concentrations higher than 50 mg/mL when tested against their respective standard drug. In case of Berberis lycium Royle when the results were compared, methanolic roots extracts showed more potent activity as compared to leaves extracts at the same concentration. It was observed that the in vitro anthelmintic potential of Punica granatum Linn. fruit peel and Berberis lyceium Royale root can be used to treat helminth infections after in vivo trails.