To maintain health and to cure diseases through Rasayana (rejuvenation) therapy along with main treatment is the unique approach of Ayurveda. The basic constituent unit of a living being is always a functional cell. Question arises from where it is generated? How it attains its final specific differentiation form? As age progresses, various changes occur at every cell level and cell undergoes to adaptation accordingly. Microenvironment for cell nourishment diminishes with age or as disease condition persists. In this context, Acharyas had contributed and documented various facts and theories through their insight wisdom. Hidden secretes in the basic principles of any medical system are needed to be explained in terms of contemporary knowledge. Contemporary research areas should be opened to include various explanations of different fields of ancient thoughts to support these new doctrines, if any. This review may be helpful to open the door of future research area in the field of reverse scientific approach of Ayurveda in the context of Dhatu Siddhanta (theory of tissues formation and differentiation) and theory of stem cell.
Keywords: Aging; Dhatu Siddhanta; Rasayana; stem cell theory.