Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer

Clara Bodelon; Svetlana Vinokurova; Joshua N Sampson; Johan A den Boon; Joan L Walker; Mark A Horswill; Keegan Korthauer; Mark Schiffman; Mark E Sherman; Rosemary E Zuna; Jason Mitchell; Xijun Zhang; Joseph F Boland; Anil K Chaturvedi; S Terence Dunn; Michael A Newton; Paul Ahlquist; Sophia S Wang; Nicolas Wentzensen

doi:10.1093/carcin/bgv171

Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer

Carcinogenesis. 2016 Feb;37(2):188-196. doi: 10.1093/carcin/bgv171. Epub 2015 Dec 9.

Authors

Clara Bodelon¹, Svetlana Vinokurova², Joshua N Sampson¹, Johan A den Boon^{3

4

5}, Joan L Walker⁶, Mark A Horswill^{3

5}, Keegan Korthauer⁷, Mark Schiffman¹, Mark E Sherman⁸, Rosemary E Zuna⁶, Jason Mitchell¹, Xijun Zhang¹, Joseph F Boland¹, Anil K Chaturvedi¹, S Terence Dunn⁶, Michael A Newton⁷, Paul Ahlquist^{3

4

5

9}, Sophia S Wang¹⁰, Nicolas Wentzensen¹

Affiliations

¹ Division of Cancer Epidemiology and Genetics , National Cancer Institute , NIH , Bethesda, MD,USA.
² Institute of Carcinogenesis , NN Blokhin Cancer Research Center , Moscow , Russia.
³ Morgridge Institute for Research.
⁴ McArdle Laboratory for Cancer Research and.
⁵ Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI, USA.
⁶ University of Oklahoma Health Sciences Center , Oklahoma City, OK,USA.
⁷ Departments of Statistics and of Biostatistics and Medical Informatics , University of Wisconsin-Madison , Madison, WI,USA.
⁸ Division of Cancer Prevention, Breast and Gynecologic Cancer Research Group, National Cancer Institute, NIH , Bethesda, MD , USA.
⁹ Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI, USA, and.
¹⁰ Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute , City of Hope, Duarte, CA,USA.

Abstract

The relationship between chromosomal instability and integration of the human papillomavirus (HPV) DNA into the host genome is not well understood. We found that chromosomal instability increases with HPV integration and diagnosis. However, chromosomal instability could occur without HPV integration.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cluster Analysis
Comparative Genomic Hybridization
Female
Gene Dosage
Genomic Instability
Human papillomavirus 16
Humans
Laser Capture Microdissection
Middle Aged
Papillomavirus Infections / virology*
Polymerase Chain Reaction
Uterine Cervical Dysplasia / genetics*
Uterine Cervical Dysplasia / virology*
Uterine Cervical Neoplasms / genetics*
Uterine Cervical Neoplasms / virology*
Virus Integration / genetics*

Abstract

Publication types

MeSH terms

Grants and funding