Intermolecular Cyclopropanation of Styrenes Using Iodine and Visible Light via Carbon-Iodine Bond Cleavage

Org Lett. 2016 Jan 4;18(1):8-11. doi: 10.1021/acs.orglett.5b02957. Epub 2015 Dec 14.

Abstract

The intermolecular cyclopropanation of aromatic olefins with activated methylene compounds using iodine and visible light irradiation was described. This reaction proceeds under rare-metal-free conditions. Styrenes with various substituted groups (alkyl and electron-withdrawing groups) provided corresponding cyclopropanes in moderate to good yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon / chemistry*
  • Catalysis
  • Cyclopropanes / chemistry*
  • Iodine / chemistry*
  • Molecular Structure
  • Styrenes / chemistry*

Substances

  • Cyclopropanes
  • Styrenes
  • Carbon
  • Iodine