TREM2 rare variant p.R47H is not associated with Parkinson's disease

David Mengel; Mathias Thelen; Monika Balzer-Geldsetzer; Charlotte Söling; Jan-Philipp Bach; Eva Schaeffer; Christine Herold; Tim Becker; Inga Liepelt; Julian Becker; Steffi Riedel-Heller; Martin Scherer; Frank Jessen; Wolfgang Maier; Richard Dodel; Alfredo Ramirez

doi:10.1016/j.parkreldis.2015.11.026

TREM2 rare variant p.R47H is not associated with Parkinson's disease

Parkinsonism Relat Disord. 2016 Feb:23:109-11. doi: 10.1016/j.parkreldis.2015.11.026. Epub 2015 Nov 25.

Authors

David Mengel¹, Mathias Thelen², Monika Balzer-Geldsetzer¹, Charlotte Söling¹, Jan-Philipp Bach³, Eva Schaeffer⁴, Christine Herold⁵, Tim Becker⁶, Inga Liepelt⁴, Julian Becker², Steffi Riedel-Heller⁷, Martin Scherer⁸, Frank Jessen⁹, Wolfgang Maier¹⁰, Richard Dodel¹, Alfredo Ramirez¹¹

Affiliations

¹ Department of Neurology, Philipps-University of Marburg, 35043 Marburg, Germany.
² Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany.
³ Department of Neurology, RWTH Aachen, 52074 Aachen, Germany.
⁴ Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tuebingen, and German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany.
⁵ German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
⁶ German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany; Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, 53127 Bonn, Germany.
⁷ Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103 Leipzig, Germany.
⁸ Department of Primary Medical Care, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany.
⁹ Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany; Department of Psychiatry and Psychotherapy, University of Cologne, 50937 Cologne, Germany.
¹⁰ Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
¹¹ Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany. Electronic address: alfredo.ramirez@ukb.uni-bonn.de.

PMID: 26651418
DOI: 10.1016/j.parkreldis.2015.11.026

Abstract

Variant p.R47H of triggering receptor expressed on myeloid cells 2 (TREM2) has been associated with Parkinson's disease (PD). We screened this TREM2-variant in 821 PD patients including 261 demented PD patients (PDD) and in healthy controls (n = 919). Neither the entire PD nor the small PDD sample was associated with p.R47H.

Keywords: Association; Dementia; Non-motor symptoms; Parkinson's disease; TREM2.

Publication types

Letter
Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Female
Genetic Predisposition to Disease / genetics*
Genetic Variation
Humans
Male
Membrane Glycoproteins / genetics*
Middle Aged
Parkinson Disease / genetics*
Polymorphism, Single Nucleotide
Receptors, Immunologic / genetics*

Substances

Membrane Glycoproteins
Receptors, Immunologic
TREM2 protein, human