[Coagulation factor XIII – Pathophysiology, clinic and therapy of factor XIII deficiency]

Anasthesiol Intensivmed Notfallmed Schmerzther. 2015 Nov;50(11-12):684-90. doi: 10.1055/s-0041-105951.
[Article in German]

Abstract

The complex activity of the transglutaminase factor XIII (FXIII) comprises central functions in secondary hemostasis. Congenital or acquired FXIII deficiencies may be associated with habitual abortions, impaired wound healing, coagulopathy and fatal hemorrhage. The present review describes physiological functions of FXIII, as well as pathophysiology, diagnostic and therapeutic options of FXIII deficiencies.

Publication types

  • Review

MeSH terms

  • Blood Coagulation Disorders / diagnosis*
  • Blood Coagulation Disorders / etiology
  • Blood Coagulation Disorders / therapy*
  • Blood Coagulation Tests / methods
  • Blood Transfusion
  • Factor XIII Deficiency / complications
  • Factor XIII Deficiency / diagnosis*
  • Factor XIII Deficiency / therapy*
  • Genetic Testing / methods
  • Hemorrhage / diagnosis*
  • Hemorrhage / etiology
  • Hemorrhage / therapy*
  • Humans
  • Immunosuppressive Agents / administration & dosage

Substances

  • Immunosuppressive Agents