A Petal-type Chiral NADH Model: Design, Synthesis and its Asymmetric Reduction

Cui-Bing Bai; Nai-Xing Wang; Yan-Jing Wang; Yalan Xing; Wei Zhang; Xing-Wang Lan

doi:10.1038/srep17458

A Petal-type Chiral NADH Model: Design, Synthesis and its Asymmetric Reduction

Sci Rep. 2015 Dec 9:5:17458. doi: 10.1038/srep17458.

Authors

Cui-Bing Bai¹, Nai-Xing Wang¹, Yan-Jing Wang¹, Yalan Xing², Wei Zhang¹, Xing-Wang Lan¹

Affiliations

¹ Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
² Department of Chemistry, William Paterson University of New Jersey, 300 Pompton Road, Wayne, New Jersey 07470, United States.

Abstract

A new type of NADH model compound has been synthesized by an efficient and convenient method. This model compound exhibits high reactivity and enantioselectivity in asymmetric reduction reactions. The results show that chiral NADH model S could be effectively combined with Mg(2+) to form ternary complexes. This novel C3 symmetrical NADH model is capable of fluorescence emission at 460 nm when excited at 377 nm.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Models, Chemical*
Models, Molecular
Molecular Conformation
NAD / chemical synthesis
NAD / chemistry*

Substances

NAD