Photocleavable Hydrogels for Light-Triggered siRNA Release

Adv Healthc Mater. 2016 Feb 4;5(3):305-310. doi: 10.1002/adhm.201500778. Epub 2015 Dec 7.

Abstract

A photocleavable hydrogel system for on-demand delivery of genetic material is reported. The release of short interfering RNAs can be triggered by the application of UV light without any loss in bioactivity. This approach provides a promising external stimulus-based nucleic acid delivery platform for applications in disease therapeutics and tissue regeneration.

Keywords: UV-controllable release; controlled release; on-demand release; photolabile hydrogels; siRNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Gene Transfer Techniques
  • Humans
  • Hydrogels / chemistry*
  • Light
  • Nucleic Acids / chemistry
  • RNA, Small Interfering / chemistry*
  • Regeneration / physiology
  • Tissue Engineering / methods

Substances

  • Hydrogels
  • Nucleic Acids
  • RNA, Small Interfering