Abstract
An architecturally complex spiroketal diterpenoid, leonuketal (1), was isolated from the aerial parts of the plant Leonurus japonicus. This compound possessed an unprecedented tetracyclic skeleton that comprised a bridged spiroketal moiety fused with a ketal-γ-lactone unit. The structure and absolute configuration were determined by spectroscopic analyses, a modified Mosher's method, and ECD (electronic circular dichroism) calculations. Leonuketal (1) showed significant vasorelaxant activity against KCl-induced contraction of rat aorta, with the EC50 value of 2.32 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aortic Coarctation / chemically induced
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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Leonurus / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Components, Aerial / chemistry
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Potassium Chloride / pharmacology
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Rats
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology
Substances
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Diterpenes
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Furans
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Spiro Compounds
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leonuketal
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spiroketal
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Potassium Chloride