Aggressive angiomyxoma (AAM) is a rare benign mesenchymal tumor that occurs almost exclusively in the soft tissues of the pelvis and perineum. Very few cases of AAM occurring outside these regions have been reported. The present report presents a case of AAM originating from the liver of a 50-year-old female patient. Tumor resection was performed, and pathological examination revealed microscopic features that were characteristic of AAM. Histopathological examination showed that the tumor was composed of scattered spindle-or stellate-shaped cells with thick-walled blood vessels lying in a myxoid stroma. Immunohistochemically, the tumor cells stained positively for CD34, vimentin, and actin. In this paper, we also discuss the differential diagnosis of AAM. To the best of our knowledge, this study is the first to report a case of AAM originating from the liver.
Keywords: Aggressive angiomyxoma; immunohistochemistry; liver.