Consumption of a calcium and vitamin D-fortified food product does not affect iron status during initial military training: a randomised, double-blind, placebo-controlled trial

Br J Nutr. 2016 Feb 28;115(4):637-43. doi: 10.1017/S0007114515004766. Epub 2015 Dec 2.

Abstract

Ca/vitamin D supplementation maintains bone health and decreases stress fracture risk during initial military training (IMT); however, there is evidence that Ca may negatively affect the absorption of other critical micronutrients, particularly Fe. The objective of this randomised, double-blind, placebo-controlled trial was to determine whether providing 2000 mg/d Ca and 25 µg/d vitamin D in a fortified food product during 9 weeks of military training affects Fe status in young adults. Male (n 98) and female (n 54) volunteers enrolled in US Army basic combat training (BCT) were randomised to receive a snack bar with Ca/vitamin D (n 75) or placebo (snack bar without Ca/vitamin D; n 77) and were instructed to consume 2 snack bars/d between meals throughout the training course. Circulating ionised Ca was higher (P0·05) in markers of Fe status between placebo and Ca/vitamin D groups. Collectively, these data indicate that Ca/vitamin D supplementation through the use of a fortified food product consumed between meals does not affect Fe status during IMT.

Keywords: BCT basic combat training; Bioavailability; Calcium/vitamin D supplementation; DMT1 divalent metal transporter 1; IMT initial military training; Iron deficiency; Minerals.

Publication types

  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Anemia, Iron-Deficiency / blood
  • Anemia, Iron-Deficiency / etiology*
  • Biomarkers / blood
  • Calcium, Dietary / adverse effects*
  • Calcium, Dietary / therapeutic use
  • Double-Blind Method
  • Female
  • Food, Fortified / adverse effects*
  • Fractures, Stress / epidemiology
  • Fractures, Stress / prevention & control
  • Humans
  • Iron, Dietary / antagonists & inhibitors*
  • Iron, Dietary / metabolism
  • Male
  • Military Personnel / education
  • Nutritional Status
  • Oklahoma / epidemiology
  • Physical Conditioning, Human / adverse effects*
  • Risk Factors
  • Snacks*
  • Stress, Physiological
  • Vitamin D / adverse effects*
  • Vitamin D / therapeutic use
  • Young Adult

Substances

  • Biomarkers
  • Calcium, Dietary
  • Iron, Dietary
  • Vitamin D