The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision

Imad J Matouk; David Halle; Eli Raveh; Michal Gilon; Vladimir Sorin; Avraham Hochberg

doi:10.18632/oncotarget.6387

The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision

Oncotarget. 2016 Jan 26;7(4):3748-65. doi: 10.18632/oncotarget.6387.

Authors

Imad J Matouk^{1

2}, David Halle¹, Eli Raveh¹, Michal Gilon¹, Vladimir Sorin¹, Avraham Hochberg¹

Affiliations

¹ Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
² Department of Biological Sciences, Faculty of Science and Technology, Al-Quds University, Jerusalem, West Bank.

Abstract

Long non-coding RNA (lncRNA) genes are emerging as key players in the metastatic cascade. Current evidence indicate that H19 lncRNA and the microRNA(miRNA) miR-675, which is processed from it, play crucial roles in metastasis, through the regulation of critical events specifically the epithelial to mesenchymal (EMT) and the mesenchymal to epithelial transitions (MET). This review summarizes recent mechanistic pathways and tries to put together seemingly conflicting data from different reports under one proposed general scheme underlying the various roles of H19/miR-675 in the metastatic cascade. We propose several approaches to harnessing this knowledge for translational medicine.

Keywords: EMT; H19; MET; lncRNA; metastasis; miR-675.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Epithelial-Mesenchymal Transition*
Gene Expression Regulation, Neoplastic*
Humans
MicroRNAs / genetics*
Neoplasm Metastasis
Neoplasms / genetics*
Neoplasms / pathology*
RNA, Long Noncoding / genetics*

Substances

H19 long non-coding RNA
MicroRNAs
RNA, Long Noncoding