New treatment models for compulsive disorders

Jon E Grant; Naomi Fineberg; Michael van Ameringen; Danielle Cath; Henny Visser; Lior Carmi; Stefano Pallanti; Eric Hollander; Anton J L M van Balkom

doi:10.1016/j.euroneuro.2015.11.008

New treatment models for compulsive disorders

Eur Neuropsychopharmacol. 2016 May;26(5):877-84. doi: 10.1016/j.euroneuro.2015.11.008. Epub 2015 Nov 18.

Authors

Jon E Grant¹, Naomi Fineberg², Michael van Ameringen³, Danielle Cath⁴, Henny Visser⁵, Lior Carmi⁶, Stefano Pallanti⁷, Eric Hollander⁸, Anton J L M van Balkom⁹

Affiliations

¹ Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Pritzker School of Medicine, 5841 S. Maryland Avenue, MC 3077, Chicago, IL 60637, USA. Electronic address: jongrant@uchicago.edu.
² Highly Specialized OCD and BDD Services, Hertfordshire Partnership University NHS Foundation Trust and University of Hertfordshire, UK.
³ Department of Psychiatry and Behavioural Neurosciences, McMaster University and MacAnxiety Research Centre, Hamilton, Ontario, Canada.
⁴ Utrecht University and Altrecht Academic Anxiety Disorders Center, Utrecht, The Netherlands.
⁵ Innova Research Centre, Mental Health Care Institute GGZ Centraal, Ermelo, The Netherlands.
⁶ Department of Psychology, Tel Aviv University, Tel Aviv, Israel; Department of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Israel.
⁷ Department of Psychiatry and Behavioral Sciences UC Davis Health System, Albert Einstein College of Medicine and Montefiore Medical Center, Sacramento, CA, USA.
⁸ Department of Psychiatry, Albert Einstein Medical School, Montefiore Medical Center, New York City, NY, USA.
⁹ Department of Psychiatry and EMGO(+) Institute, VU-University Medical Centre and GGZ ingest, Amsterdam, The Netherlands.

PMID: 26621260
DOI: 10.1016/j.euroneuro.2015.11.008

Abstract

Obsessive compulsive disorder (OCD) as well as related disorders such as body dysmorphic disorder, tic disorder, and trichotillomania are all common and often debilitating. Although treatments are available, more effective approaches to these problems are needed. Thus this review article presents what is currently known about OCD and related disorders and suggests that understanding OCD more broadly as a compulsive disorder may allow for more effective treatment options. Toward that goal, the review presents new models of psychopharmacology and psychotherapy, as well as new brain stimulation strategies. Treatment advances, grounded in the neuroscience, have promise in advancing treatment response for OCD as well as other disorders of compulsivity.

Keywords: Compulsivity; Obsession; Pharmacotherapy; Psychotherapy.

Publication types

Review

MeSH terms

Antipsychotic Agents / therapeutic use*
Biomedical Research / trends
Body Dysmorphic Disorders / diagnosis
Body Dysmorphic Disorders / drug therapy
Body Dysmorphic Disorders / physiopathology
Body Dysmorphic Disorders / therapy
Cognitive Remediation
Combined Modality Therapy / trends
Compulsive Behavior / diagnosis
Compulsive Behavior / drug therapy
Compulsive Behavior / physiopathology
Compulsive Behavior / therapy*
Compulsive Personality Disorder / diagnosis
Compulsive Personality Disorder / drug therapy
Compulsive Personality Disorder / physiopathology
Compulsive Personality Disorder / therapy*
Deep Brain Stimulation / trends
Drugs, Investigational / therapeutic use*
Habits
Humans
Models, Neurological*
Nervous System / drug effects
Nervous System / physiopathology
Obsessive-Compulsive Disorder / diagnosis
Obsessive-Compulsive Disorder / drug therapy
Obsessive-Compulsive Disorder / physiopathology
Obsessive-Compulsive Disorder / therapy*
Psychotherapy* / trends
Terminology as Topic
Therapies, Investigational / trends
Transcranial Magnetic Stimulation / trends
Trichotillomania / diagnosis
Trichotillomania / drug therapy
Trichotillomania / physiopathology
Trichotillomania / therapy

Substances

Antipsychotic Agents
Drugs, Investigational