BAFF inhibition does not significantly impair immunization responses in patients with rheumatoid arthritis

Arthritis Res Ther. 2015 Nov 30:17:347. doi: 10.1186/s13075-015-0867-z.

Authors

Clifton O Bingham 3rd¹, Kevin L Winthrop², Lili Yang³, Chin Lee³, Wendy J Komocsar³

Affiliations

¹ Division of Rheumatology, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Mason F. Lord Center Tower Room 404, Baltimore, MD, 21224, USA. cbingha2@jhmi.edu.
² Divisions of Infectious Diseases, Public Health, and Preventive Medicine, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR, 97239, USA.
³ Eli Lilly and Company, Indianapolis, IN, 46285, USA.

No abstract available

Publication types

Letter
Randomized Controlled Trial

MeSH terms

Adult
Aged
Antibodies, Monoclonal / immunology
Antibodies, Monoclonal / therapeutic use*
Antibodies, Monoclonal, Humanized
Arthritis, Rheumatoid / drug therapy*
Arthritis, Rheumatoid / immunology
B-Cell Activating Factor / antagonists & inhibitors*
B-Cell Activating Factor / immunology
B-Lymphocytes / drug effects
B-Lymphocytes / immunology
B-Lymphocytes / metabolism
Diphtheria-Tetanus-acellular Pertussis Vaccines / administration & dosage
Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology
Double-Blind Method
Drug Administration Schedule
Drug Therapy, Combination
Female
Humans
Immunoglobulins / immunology
Immunoglobulins / metabolism
Immunosuppressive Agents / immunology
Immunosuppressive Agents / therapeutic use
Lymphocyte Count
Male
Methotrexate / immunology
Methotrexate / therapeutic use*
Middle Aged
Time Factors
Treatment Outcome
Vaccination / methods

Substances

Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
B-Cell Activating Factor
Diphtheria-Tetanus-acellular Pertussis Vaccines
Immunoglobulins
Immunosuppressive Agents
tabalumab
Methotrexate