Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma

Hidetaka Sugihara; Takatsugu Ishimoto; Keisuke Miyake; Daisuke Izumi; Yoshifumi Baba; Naoya Yoshida; Masayuki Watanabe; Hideo Baba

doi:10.3390/ijms161126060

Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma

Int J Mol Sci. 2015 Nov 24;16(11):27824-34. doi: 10.3390/ijms161126060.

Authors

Hidetaka Sugihara¹, Takatsugu Ishimoto^{2

3}, Keisuke Miyake⁴, Daisuke Izumi⁵, Yoshifumi Baba⁶, Naoya Yoshida⁷, Masayuki Watanabe⁸, Hideo Baba⁹

Affiliations

¹ Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan. hidetaka1125@hotmail.com.
² Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan. taka1516@kumamoto-u.ac.jp.
³ Cancer and Stem Cell Biology, Duke-National University of Singapore (NUS) Graduate Medical School Singapore, Singapore 169857, Singapore. taka1516@kumamoto-u.ac.jp.
⁴ Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan. technical.assistant.kugs01@gmail.com.
⁵ Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan. apple_morphine@yahoo.co.jp.
⁶ Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan. baba@kumamoto-u.ac.jp.
⁷ Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan. nyoshida@kumamoto-u.ac.jp.
⁸ Department of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation For Cancer Research (JFCR), Tokyo 135-8550, Japan. masayuki.watanabe@jfcr.or.jp.
⁹ Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan. hdobaba@kumamoto-u.ac.jp.

Abstract

Esophageal cancer is one of the most common cancers worldwide. Esophageal squamous cell carcinoma (ESCC) is the major histological type of esophageal cancer in Eastern Asian countries. Several types of noncoding RNAs (ncRNAs) function as key epigenetic regulators of gene expression and are implicated in various physiological processes. Unambiguous evidence indicates that dysregulation of ncRNAs is deeply implicated in carcinogenesis, cancer progression and metastases of various cancers, including ESCC. The current review summarizes recent findings on the ncRNA-mediated mechanisms underlying the characteristic behaviors of ESCC that will help support the development of biomarkers and the design of novel therapeutic strategies.

Keywords: biomarker; cancer development; cancer initiation; esophageal squamous cell carcinoma; long noncoding RNA; microRNA.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use
Biomarkers, Tumor
Carcinoma, Squamous Cell / diagnosis
Carcinoma, Squamous Cell / drug therapy
Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / pathology*
Cell Line, Tumor
Cell Movement / genetics
Cell Transformation, Neoplastic / genetics
Disease Progression
Drug Resistance, Neoplasm / genetics
Esophageal Neoplasms / diagnosis
Esophageal Neoplasms / drug therapy
Esophageal Neoplasms / genetics*
Esophageal Neoplasms / pathology*
Esophageal Squamous Cell Carcinoma
Gene Expression Regulation, Neoplastic*
Humans
MicroRNAs / blood
MicroRNAs / genetics
Neoplasm Invasiveness
Prognosis
RNA, Long Noncoding / genetics
RNA, Untranslated / genetics*

Substances

Antineoplastic Agents
Biomarkers, Tumor
MicroRNAs
RNA, Long Noncoding
RNA, Untranslated