Complement factor H in its alternative identity as adrenomedullin-binding protein 1

Mol Immunol. 2015 Nov;68(1):45-8. doi: 10.1016/j.molimm.2015.06.006.

Abstract

Complement factor H has been extensively studied since its discovery 50 years ago, and its role in the complement system is quite well established. It has another role, however, as a binding protein for the regulatory peptide adrenomedullin. Part of this role appears to be protection of adrenomedullin from proteolytic degradation. The binding interaction is unusual and merits further investigation. Adrenomedullin has potential therapeutic uses in diseases affecting the vasculature, and factor H has been administered with adrenomedullin in some animal models of disease.

Keywords: AMBP1; Adrenomedullin; Complement; Factor H; Haemorrhage; Protein–protein interaction; Sepsis.

Publication types

  • Review

MeSH terms

  • Adrenomedullin / genetics
  • Adrenomedullin / immunology*
  • Adrenomedullin / pharmacology
  • Animals
  • Binding Sites
  • Complement Factor H / genetics
  • Complement Factor H / immunology*
  • Complement Factor H / pharmacology
  • Disease Models, Animal
  • Gene Expression
  • Hemorrhage / drug therapy
  • Hemorrhage / genetics
  • Hemorrhage / immunology*
  • Hemorrhage / pathology
  • Humans
  • Protein Binding
  • Protein Stability
  • Protein Structure, Tertiary
  • Proteolysis
  • Reperfusion Injury / drug therapy
  • Reperfusion Injury / genetics
  • Reperfusion Injury / immunology*
  • Reperfusion Injury / pathology
  • Sepsis / drug therapy
  • Sepsis / genetics
  • Sepsis / immunology*
  • Sepsis / pathology

Substances

  • ADM protein, human
  • adrenomedullin-binding protein 1, human
  • Adrenomedullin
  • Complement Factor H